Integrated Study of Transcriptome-wide m⁶A Methylome Reveals Novel Insights Into the Character and Function of m⁶A Methylation During Yak Adipocyte Differentiation.

ABSTRACT: Yak (Bos grunniens) is considered an iconic symbol of Tibet and high altitude, but they suffer from malnutrition during the cold season that challenges the metabolism of energy. Adipocytes perform a crucial role in maintaining the energy balance, and adipocyte differentiation is a complex process involving multiple changes in the expression of genes. N ⁶-methyladenosine (m⁶A) plays a dynamic role in post-transcription gene expression regulation as the most widespread mRNA modification of the higher eukaryotes. However, currently there is no research existing on the m⁶A transcriptome-wide map of bovine animals and their potential biological functions in adipocyte differentiation. Therefore, we performed methylated RNA immunoprecipitation sequen

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8678508 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature