CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study.

ABSTRACT:

Introduction

Most existing vaccines require higher or additional doses or adjuvants to provide similar protection for people living with HIV (PLWH) compared with HIV-uninfected individuals. Additional research is necessary to inform COVID-19 vaccine use in PLWH.

Methods and analysis

This multicentred observational Canadian cohort study will enrol 400 PLWH aged >16 years from Montreal, Ottawa, Toronto and Vancouver. Subpopulations of PLWH of interest will include individuals: (1) >55 years of age; (2) with CD4 counts <350 cells/mm³; (3) with multimorbidity (>2 comorbidities) and (4) 'stable' or 'reference' PLWH (CD4 T cells >350 cells/mm³, suppressed viral load for >6 months and <1 comorbidity). Data for 1000 HIV-negative cont

SUBMITTER: Costiniuk CT 

PROVIDER: S-EPMC8678543 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature