Comprehensive Analysis Identified ETV7 as a Potential Prognostic Biomarker in Bladder Cancer.

ABSTRACT:

Background

The tumor microenvironment (TME) plays a crucial role in the initiation and progression of cancer. Bladder cancer (BLCA) is a malignant tumor of the genitourinary system. Its heterogeneity results in significant differences in the prognosis of patients. To date, this is still a huge challenge for clinical treatment. In recent years, more and more evidence showed that dysregulation of transcription factors (TFs) plays an important role in tumor progression, invasion, and metastasis. Unfortunately, the role of TFs on the tumor microenvironment in bladder cancer is unclear.

Methods

The original data of BLCA and corresponding adjacent tissues were obtained from The Cancer Genome Atlas (TCGA) database. TFs were downloaded from the Animal Transcription Factor DataBase (

SUBMITTER: Li H 

PROVIDER: S-EPMC8678556 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature