The Key Genes Underlying Pathophysiology Association between Plaque Instability and Progression of Myocardial Infarction.

ABSTRACT: Young patients with type 2 diabetes and myocardial infarction (MI) have higher long-term all-cause and cardiovascular mortality. In addition, the observed increased, mildly abnormal baseline lipid levels, but not lipid variability, are associated with an increased risk of atherosclerotic cardiovascular disease events, particularly MI. This study investigated differentially expressed genes (DEGs), which might be potential targets for young patients with MI and a high-fat diet (HFD). GSE114695 and GSE69187 were downloaded and processed using the limma package. A Venn diagram was applied to identify the same DEGs, and further pathway analysis was performed using Metascape. Protein-protein interaction (PPI) network analysis was then applied, and the hub genes were screened out. Pivotal miRNAs

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC8678557 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature