Synthesizing Core Outcome Sets for outcomes research in cohort studies: a systematic review.

ABSTRACT:

Background

Life course studies are designed to "collect once, use multiple times" for observational and, increasingly, interventional research. Core Outcome Sets (COS) are minimum sets developed for clinical trials by multi-stakeholder consensus methodologies. We aimed to synthesize published COS that might guide outcomes selection for early life cohorts with an interventional focus.

Methods

We searched PubMed, Medline, COMET, and CROWN for COS published before January 2021 relevant to four life stages (pregnancy, newborns, children <8 years, and parents (adults aged 18-50 years)). We synthesized core outcomes into overarching constructs.

Results

From 46 COS we synthesized 414 core outcomes into 118 constructs. "Quality of life", "adverse events", "medication use", "h

SUBMITTER: Musgrove E 

PROVIDER: S-EPMC8678579 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature