Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function.

ABSTRACT:

Importance

The risk of airflow limitation and chronic obstructive pulmonary disease (COPD) is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains unclear whether gene-by-smoking interactions are associated with quantitative measures of lung function.

Objective

To assess the interaction of cigarette smoking and polygenic risk score in association with reduced lung function.

Design, setting, and participants

This UK Biobank cohort study included UK citizens of European ancestry aged 40 to 69 years with genetic and spirometry data passing quality control metrics. Data was analyzed from July 2020 to March 2021.

Exposures

PRS of combined forced expiratory volume in 1 second (FEV1) and percent of forced vital capacity exhaled in

SUBMITTER: Kim W 

PROVIDER: S-EPMC8678715 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature