Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC8678996 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Yang Shuo S Zhu Xiao-Na XN Zhang Hui-Lin HL Yang Qian Q Wei Yu-Sheng YS Zhu Di D Liu Meng-Di MD Shen Shao-Ming SM Xia Li L He Ping P Ge Meng-Kai MK Pan Yi-Lian YL Zhao Meng M Wu Ying-Li YL Zheng Jun-Ke JK Chen Guo-Qiang GQ Yu Yun Y
Blood 20211201 24
Proper regulation of p53 signaling is critical for the maintenance of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). The hematopoietic cell-specific mechanisms regulating p53 activity remain largely unknown. Here, we demonstrate that conditional deletion of acidic leucine-rich nuclear phosphoprotein 32B (ANP32B) in hematopoietic cells impairs repopulation capacity and postinjury regeneration of HSCs. Mechanistically, ANP32B forms a repressive complex with p53 and thus inhibits t ...[more]