Two-step versus 1-step subretinal injection to compare subretinal drug delivery: a randomised study protocol.

ABSTRACT:

Introduction

There is increasing interest in subretinal injections as a surgical procedure, largely as a result of emerging treatments for ocular diseases which necessitate this manoeuvre. However, surgical variables in the efficacy of such treatments have to date been largely overlooked and the proportion of drug which reaches the intended compartment of the subretinal space remains unknown. Our aims are twofold: first, to determine the proportion of subretinally injected medication retained following surgical delivery and second, to compare two different techniques of injection ('1-step' vs '2-step').

Methods

We outline a randomised controlled trial of subretinal injection of alteplase following vitrectomy for the management of submacular haemorrhage secondary to age-relat

SUBMITTER: Simunovic MP 

PROVIDER: S-EPMC8679105 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature