Interleukin-2-inducible T-cell kinase (Itk) signaling regulates potent noncanonical regulatory T cells.

ABSTRACT: Regulatory T cells (Tregs) play an important role in controlling autoimmunity and limiting tissue damage and inflammation. IL2-inducible T cell kinase (Itk) is part of the Tec family of tyrosine kinases and is a critical component of T cell receptor mediated signaling. Here, we showed that either genetic ablation of Itk signaling or inhibition of Itk signaling pathways resulted in increased frequency of "noncanonical" CD4⁺ CD25^- FOXP3⁺ Tregs (ncTregs), as well as of "canonical" CD4⁺ CD25⁺ FOXP3⁺ Tregs (canTregs). Using in vivo models, we showed that ncTregs can avert the formation of acute graft-versus-host disease (GVHD), in part by reducing conventional T cell proliferation, proinflammatory cytokine production, and tissue

SUBMITTER: Mammadli M 

PROVIDER: S-EPMC8679839 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature