S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study.

ABSTRACT:

Objective

Adrenocortical carcinoma (ACC) has an aggressive but variable clinical course. Prognostic stratification based on the European Network for the Study of Adrenal Tumours stage and Ki67 index is limited. We aimed to demonstrate the prognostic role of a points-based score (S-GRAS) in a large cohort of patients with ACC.

Design

This is a multicentre, retrospective study on ACC patients who underwent adrenalectomy.

Methods

The S-GRAS score was calculated as a sum of the following points: tumour stage (1-2 = 0; 3 = 1; 4 = 2), grade (Ki67 index 0-9% = 0; 10-19% = 1; ≥20% = 2 points), resection status (R0 = 0; RX = 1; R1 = 2; R2 = 3), age (<50 years = 0; ≥50 years = 1), symptoms (no = 0; yes = 1), and categorised, generating four groups (0-1, 2-3, 4-5, and 6-9). Endp

SUBMITTER: Elhassan YS 

PROVIDER: S-EPMC8679848 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature