Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance and impaired energy metabolism in skeletal muscle, the aetiology of which is currently unclear. Here, we mapped the gene expression profile of skeletal muscle from women with PCOS and determined if cultured primary myotubes retain the gene expression signature of PCOS in vivo. Transcriptomic analysis of vastus lateralis biopsies collected from PCOS women showed lower expression of genes associated with mitochondrial function, while the expression of genes associated with the extracellular matrix was higher compared to controls. Altered skeletal muscle mRNA expression of mitochondrial-associated genes in PCOS was associated with lower protein expression of mitochondrial complex II-V, but not c

SUBMITTER: Moreno-Asso A 

PROVIDER: S-EPMC8679849 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature