ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs.

ABSTRACT:

Background

Reactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and redox sensing. ROMO1 regulates ROS generation within cells and is involved in cellular processes, such as cell proliferation, senescence, and death. Our purpose is to investigates the impact of ROMO1 on the mitochondria during porcine embryogenesis.

Results

We found that high expression of ROMO1 was associated with porcine preimplantation embryo development, indicating that ROMO1 may contribute to the progression of embryogenesis. Knockdown of ROMO1 disrupted porcine embryo development and blastocyst quality, thereby inducing ROS production and decreasing mitochondrial membrane potential. Knockdown of ROMO1

SUBMITTER: Zhou D 

PROVIDER: S-EPMC8680150 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature