IRF4-activated TEX41 promotes the malignant behaviors of melanoma cells by targeting miR-103a-3p/C1QB axis.

ABSTRACT:

Background

Malignant melanoma is an aggressive skin cancer and a tumor of melanocytic origin. Recent studies have suggested that long non-coding RNAs (lncRNAs) play crucial regulatory roles in multiple malignancies, including melanoma. Testis expressed 41 (TEX41) is a relatively new lncRNA whose mechanism in melanoma remains vague.

Aims

This study aimed to explore the role and specific mechanism of TEX41 in melanoma.

Methods

The expression of genes involved in this study was determined by qRT-PCR. Functional assays were conducted to analyze the role of relevant genes in melanoma cells. The interaction between TEX41 promoter and IRF4 as well as the relationship among TEX41, miR-103a-3p and C1QB was verified by mechanism assays.

Results

IRF4 up-regulated TEX41 at

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC8680380 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature