Hippocampal Volume Is Smaller In Female Double Carriers Of Two Strongest AD Genetic Risk Factors

ABSTRACT: Abstract Genetic risk factors for Alzheimer’s disease (AD) may facilitate AD-related changes in the brain long before AD clinical manifestation. While APOE4 was linked to a reduced hippocampal volume (HV) in a number of studies, the impact of rs2075650, another polymorphism strongly associated with AD, on HV is less clear. The rs2075650 (in TOMM40) is only in moderate to low LD with APOE4, and may have independent effects on HV or interact with APOE4. We studied associations of rs2075650 (G allele, risk factor for AD), rs429358 (C allele, proxy for APOE4), and their combinations, with right HV measured by MRI, among 10,738 women and 9,775 men aged 60-75, from UK Biobank. We found that right HV was significantly (p<0.02) smaller in women who carry both AD risk variants (rs2075650(G) and rs4

SUBMITTER: Ukraintseva S 

PROVIDER: S-EPMC8681000 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature