Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults.

ABSTRACT: Cardiovascular disease (CVD) is associated with a higher risk of developing dementia. Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and tau burden, which are hallmark neuropathologies of Alzheimer's disease (AD). Evidence for these associations during the preclinical stages of AD, when Aβ and tau pathologies first become detectable, is mixed. Quantifying the effect of vascular risk among cognitively normal individuals can help focus the efforts to develop therapeutic approaches aimed at modifying the course of preclinical AD. Using Bayesian analysis, we examined the relationship of Aβ and tau pathology with concurrent vascular risk among 87 cognitively normal individuals (median age 77, interquartile range 70-83) in the Baltimore Longitudinal Stud

SUBMITTER: Bilgel M 

PROVIDER: S-EPMC8682073 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature