Ontology highlight
ABSTRACT:
SUBMITTER: Jackson LM
PROVIDER: S-EPMC8682781 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Jackson Lindsey M LM Dhoonmoon Ashna A Hale Anastasia A Dennis Kady A KA Schleicher Emily M EM Nicolae Claudia M CM Moldovan George-Lucian GL
Nucleic acids research 20211201 22
Understanding chemoresistance mechanisms in BRCA-deficient cells will allow for identification of biomarkers for predicting tumor response to therapy, as well as the design of novel therapeutic approaches targeting this chemoresistance. Here, we show that the protein MED12, a component of the Mediator transcription regulation complex, plays an unexpected role in regulating chemosensitivity in BRCA-deficient cells. We found that loss of MED12 confers resistance to cisplatin and PARP inhibitors in ...[more]