Ontology highlight
ABSTRACT:
SUBMITTER: Dixit S
PROVIDER: S-EPMC8682783 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Dixit Sameer S Kessler Alan C AC Henderson Jeremy J Pan Xiaobei X Zhao Ruoxia R D'Almeida Gabriel Silveira GS Kulkarni Sneha S Rubio Mary Anne T MAT Hegedűsová Eva E Ross Robert L RL Limbach Patrick A PA Green Brian D BD Paris Zdeněk Z Alfonzo Juan D JD
Nucleic acids research 20211201 22
Every type of nucleic acid in cells undergoes programmed chemical post-transcriptional modification. Generally, modification enzymes use substrates derived from intracellular metabolism, one exception is queuine (q)/queuosine (Q), which eukaryotes obtain from their environment; made by bacteria and ultimately taken into eukaryotic cells via currently unknown transport systems. Here, we use a combination of molecular, cell biology and biophysical approaches to show that in Trypanosoma brucei tRNA ...[more]