Progressive Multiple Sclerosis Is Associated with Faster and Specific Retinal Layer Atrophy.

ABSTRACT:

Objective

Therapeutic development in progressive multiple sclerosis (PMS) has been hampered by a lack of reliable biomarkers to monitor neurodegeneration. Optical coherence tomography (OCT)-derived retinal measures have been proposed as promising biomarkers to fulfill this role. However, it is unclear whether retinal atrophy persists in PMS, exceeds normal aging, or can be distinguished from relapsing-remitting multiple sclerosis (RRMS).

Methods

178 RRMS, 186 PMS, and 66 control participants were followed with serial OCT for a median follow-up of 3.7 years.

Results

The estimated proportion of peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell + inner plexiform layer (GCIPL) thinning in multiple sclerosis (MS) attributable to normal aging increas

SUBMITTER: Sotirchos ES 

PROVIDER: S-EPMC8682917 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature