Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state.

ABSTRACT: Recent years have seen compelling demonstrations of the importance of behavioral state on sensory processing and attention. Arousal plays a dominant role in controlling brain-wide neural activity patterns, particularly through modulation by norepinephrine. Noradrenergic brainstem nuclei, including locus coeruleus, can be activated by stimuli of multiple sensory modalities and broadcast modulatory signals via axonal projections throughout the brain. This organization might suggest proportional brain-wide norepinephrine release during states of heightened vigilance. Here, however, we have found that low-intensity, nonarousing visual stimuli enhanced vigilance-dependent noradrenergic signaling locally in visual cortex, revealed using dual-site fiber photometry to monitor noradrenergic Ca

SUBMITTER: Gray SR 

PROVIDER: S-EPMC8682997 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature