Ontology highlight
ABSTRACT:
SUBMITTER: Carreras-Sureda A
PROVIDER: S-EPMC8683079 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Carreras-Sureda Amado A Abrami Laurence L Ji-Hee Kim K Wang Wen-An WA Henry Christopher C Frieden Maud M Didier Monica M van der Goot F Gisou FG Demaurex Nicolas N
eLife 20211216
Efficient immune responses require Ca<sup>2+</sup> fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel at residue Cys143 promotes TCR recruitment and signaling at the IS. Cys143 mutations reduced ORAI1 currents and store-operated Ca<sup>2+</sup> entry in HEK-293 cells and nearly abrogated long-lasting Ca<sup>2+</sup> elevations, NFATC1 ...[more]