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Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.

ABSTRACT: Ageing-related proteins play various roles such as regulating cellular ageing, countering oxidative stress, and modulating signal transduction pathways amongst many others. Hundreds of ageing-related proteins have been identified, however the functions of most of these ageing-related proteins are not known. Here, we report the identification of proteins that extended yeast chronological life span (CLS) from a screen of ageing-related proteins. Three of the CLS-extending proteins, Ptc4, Zwf1, and Sme1, contributed to an overall higher survival percentage and shorter doubling time of yeast growth compared to the control. The CLS-extending proteins contributed to thermal and oxidative stress responses differently, suggesting different mechanisms of actions. The overexpression of Ptc4 or Zwf1 also promoted rapid cell proliferation during yeast growth, suggesting their involvement in cell division or growth pathways.

SUBMITTER: Lee JW 

PROVIDER: S-EPMC8683414 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.

Lee Jee Whu JW   Ong Tee Gee TG   Samian Mohammed Razip MR   Teh Aik-Hong AH   Watanabe Nobumoto N   Osada Hiroyuki H   Ong Eugene Boon Beng EBB  

Scientific reports 20211217 1

Ageing-related proteins play various roles such as regulating cellular ageing, countering oxidative stress, and modulating signal transduction pathways amongst many others. Hundreds of ageing-related proteins have been identified, however the functions of most of these ageing-related proteins are not known. Here, we report the identification of proteins that extended yeast chronological life span (CLS) from a screen of ageing-related proteins. Three of the CLS-extending proteins, Ptc4, Zwf1, and  ...[more]

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