Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.

ABSTRACT: Ageing-related proteins play various roles such as regulating cellular ageing, countering oxidative stress, and modulating signal transduction pathways amongst many others. Hundreds of ageing-related proteins have been identified, however the functions of most of these ageing-related proteins are not known. Here, we report the identification of proteins that extended yeast chronological life span (CLS) from a screen of ageing-related proteins. Three of the CLS-extending proteins, Ptc4, Zwf1, and Sme1, contributed to an overall higher survival percentage and shorter doubling time of yeast growth compared to the control. The CLS-extending proteins contributed to thermal and oxidative stress responses differently, suggesting different mechanisms of actions. The overexpression of Ptc4 or Zwf1

SUBMITTER: Lee JW 

PROVIDER: S-EPMC8683414 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature