Identification of a prognostic immune-related signature for small cell lung cancer.

ABSTRACT:

Purpose

As a subgroup of lung cancer, small cell lung cancer (SCLC) is characterized by a short tumor doubling time, high rates of early occurred distant cancer spread, and poor outcomes. Despite its exquisite sensitivity to chemotherapy and radiotherapy, acquired drug resistance and tumor progression are typical. This study aimed to develop a robust signature based on immune-related genes to predict the outcome of patients with SCLC.

Methods

The expression data of 77 SCLC patients from George's cohort were divided into training set and testing set, and 1534 immune-related genes from ImmPort database were used to generate and validate the signature. Cox proportional hazards and the Kaplan-Meier analysis were used for developing and testing the prognostic signature. Single-sa

SUBMITTER: Xie Q 

PROVIDER: S-EPMC8683526 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature