Association between somatic RET mutations and clinical and genetic characteristics in patients with metastatic colorectal cancer.

ABSTRACT:

Background

Rearranged during transfection (RET) is a targetable oncogene. RET fusions have been reported in patients with metastatic colorectal cancer (mCRC). However, RET mutations in mCRC are less studied. Here, we aimed to characterize the clinical, pathological, and molecular landscape of RET-mutated mCRC.

Methods

Five hundred and eighty-two patients were included in this study. Next-generation sequencing was performed to detect RET mutations and calculate tumor mutation burden (TMB). We compared the clinical, pathological, and molecular characteristics of mCRC cases with tumors that harbored somatic RET mutations (N = 16, 2.7%) or had wild-type RET (N = 566, 97.3%).

Results

Males comprised the absolute majority of cases with RET mutations (15/16 [93.8%]) compared

SUBMITTER: Yang YZ 

PROVIDER: S-EPMC8683541 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature