Gene expression of oxidative stress markers and lung function: A CARDIA lung study.

ABSTRACT:

Background

Circulating markers of oxidative stress have been associated with lower lung function. Our objective was to study the association of gene expression levels of oxidative stress pathway genes (ALOX12, ALOX15, ARG2, GSTT1, LPO, MPO, NDUFB3, PLA2G7, and SOD3) and lung function forced expiratory volume in one second (FEV₁ ), forced vital capacity (FVC) in Coronary Artery Risk Development in Young Adults study.

Methods

Lung function was measured using spirometry and the Nanostring platform was used to estimate gene expression levels. Linear regression models were used to study association of lung function measured at year 30, 10-year decline in lung function and gene expression after adjustment for center, smoking, and BMI, measured at year 25.

Results

SUBMITTER: Ramasubramanian R 

PROVIDER: S-EPMC8683624 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature