Antiseizure medications and oral contraceptives: Impact of enzyme inducers on pregnancy outcomes and costs.

ABSTRACT:

Purpose

To show the impact of drug-drug interactions (DDIs) associated with co-administration of enzyme-inducing (EI) antiseizure medications and oral contraceptives (OCs) on the annual number of unintended pregnancies, their outcomes, and their associated costs in the United States (US).

Methods

A Microsoft Excel pregnancy-outcomes model was developed to determine the impact of DDIs in women who take an OC as well as an EI antiseizure medication known to lower the effectiveness of the OC in preventing pregnancy. The model compared the number of unintended pregnancies, the expected pregnancy outcomes, and associated costs in women taking an OC and an EI medication with a matched cohort of women who took an OC and an enzyme-neutral (EN) antiseizure medication that is known no

SUBMITTER: Anderson S 

PROVIDER: S-EPMC8683747 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature