Effects of chronic dietary nitrate supplementation on longevity, vascular function and cancer incidence in rats.

ABSTRACT:

Rationale

Dietary nitrate and nitrite have a notoriously bad reputation because of their proposed association with disease, in particular cancer. However, more recent lines of research have challenged this dogma suggesting that intake of these anions also possess beneficial effects after in vivo conversion to the vital signaling molecule nitric oxide. Such effects include improvement in cardiovascular, renal and metabolic function, which is partly mediated via reduction of oxidative stress. A recent study even indicates that low dose of dietary nitrite extends life span in fruit flies.

Methods

In this study, 200 middle-aged Wistar rats of both sexes were supplemented with nitrate or placebo in the drinking water throughout their remaining life and we studied longevity, bioch

SUBMITTER: Carvalho LRRA 

PROVIDER: S-EPMC8683768 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature