Developing a synthetic control group using electronic health records: Application to a single-arm lifestyle intervention study.

ABSTRACT: The electronic health records (EHR) infrastructure offers a tremendous resource for identifying controls who match the characteristics of study participants in a single-arm trial. The objectives are to (1) demonstrate the feasibility of curating a synthetic control group for an existing study cohort through EHR data extraction and (2) evaluate the effect of a lifestyle intervention on selected cardiovascular health metrics. A total of 711 university employees were recruited between 2008 and 2012 to participate in a health partner intervention to improve cardiovascular health and were followed for five years. Data of nearly 8000 eligible subjects were extracted from the EHR to create a synthetic control cohort during the same study period. To minimize confounding, crude comparison, exact ma

SUBMITTER: Ko YA 

PROVIDER: S-EPMC8683890 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature