PEDOT-AuNPs-based impedimetric immunosensor for the detection of SARS-CoV-2 antibodies.

ABSTRACT: Electrochemical sensors and biosensors are useful techniques for fast, inexpensive, sensitive, and easy detection of innumerous specimen. In face of COVID-19 pandemic, it became evident the necessity of a rapid and accurate diagnostic test, so the impedimetric immunosensor approach can be a good alternative to replace the conventional tests due to the specific antibody-antigen binding interaction and the fast response in comparison to traditional methods. In this work, a modified electrode with electrosynthesized PEDOT and gold nanoparticles followed by the immobilization of truncated nucleoprotein (N aa160-406aa) was used for a fast and reliable detection of antibodies against COVID-19 in human serum sample. The method consists in analyzing the charge-transfer resistance (R_CT)

SUBMITTER: Lorenzen AL 

PROVIDER: S-EPMC8684030 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature