Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma cancer.

ABSTRACT:

Backgrounds

Osteosarcomas are one of the most common primary malignant tumors of bone. It primarily occurs in children and adolescents, with the second highest incidence among people over 50 years old. Although there were immense improvements in the survival of patients with osteosarcoma in the past 30 years, targetable mutations and agents of osteosarcomas still have been generally not satisfactory. Therefore, it is of great importance to further explore the highly specialized immune environment of bone, genes related to macrophage infiltration and potential therapeutic biomarkers and targets.

Methods

The 11 expression data sets of OS tissues and the 11 data sets of adjacent non-tumorous tissues available in the GEO database GSE126209 were used to conduct immune infiltratio

SUBMITTER: Liu R 

PROVIDER: S-EPMC8684084 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature