Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift.

ABSTRACT:

Background

Liver fibrosis is a wound-healing response to tissue injury and inflammation hallmarked by the extracellular matrix (ECM) protein deposition in the liver parenchyma and tissue remodelling. Different cell types of the liver are known to play distinct roles in liver injury response. Hepatocytes and liver endothelial cells receive molecular signals indicating tissue injury and activate hepatic stellate cells which produce ECM proteins upon their activation. Despite the growing knowledge on the molecular mechanism underlying hepatic fibrosis in general, the cell-type-specific gene regulatory network associated with the initial response to hepatotoxic injury is still poorly characterized.

Results

In this study, we used thioacetamide (TAA) to induce hepatic injury in ad

SUBMITTER: Migdal M 

PROVIDER: S-EPMC8684102 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature