Altered microRNAs in C3H10T1/2 cells induced by p.E95K mutant IHH signaling.

ABSTRACT:

Background

Indian Hedgehog (IHH), an important cell signaling protein, plays a key regulatory role in development of cartilage and chondrogenesis. Earlier studies have shown that heterozygous missense mutations in IHH gene may cause brachydactyly type A1 (BDA1), an autosomal dominant inheritance disease characterized by apparent shortness or absence of the middle phalanges of all digits. MicroRNAs (miRNAs) have been found to be significant post-transcriptional regulators of gene expression and significantly influence the process of bone-development. Therefore, it is possible that miRNAs are involved in the mechanism underlying the development of BDA1. However, the relationship between miRNAs and the pathogenesis of BDA1 remains unclear.

Methods

In this study, we used microar

SUBMITTER: Zhou W 

PROVIDER: S-EPMC8684136 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature