Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro.

ABSTRACT:

Objective

Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette transporter responsible for the uptake and efflux process, which leads to resistance. Many natural products have shown potential to compete with ATP binding cassette transporter and may sensitize resistant cells to cisplatin. Studies have shown pro-oxidant effect of carotenoids that promote apoptosis of cancer cells. Bixin and fucoxanthin are well-known carotenoids with known antioxidant properties, however their bioactivity in lung cancer cells, clinically known to develop resistance due to ATP binding cassette transporter, has been minimally studied. This study is the first to investigate the

SUBMITTER: Nurcahyanti ADR 

PROVIDER: S-EPMC8684137 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature