Pharmacometabolomic profiles in type 2 diabetic subjects treated with liraglutide or glimepiride.

ABSTRACT:

Background

Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) leads to multiple metabolic changes, reduction in glucose levels and body weight are well established. In people with type 2 diabetes, GLP-1 RAs reduce the risk of cardiovascular (CV) disease and may also potentially represent a treatment for fatty liver disease. The mechanisms behind these effects are still not fully elucidated. The aim of the study was to investigate whether treatment with liraglutide is associated with favourable metabolic changes in cases of both CV disease and fatty liver disease.

Methods

In a prespecified post-hoc analysis of a double-blind, placebo-controlled trial in 62 individuals with type 2 diabetes (GLP-1 RA liraglutide or glimepiride, both in combination with metform

SUBMITTER: Jendle J 

PROVIDER: S-EPMC8684205 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature