Albumin and fibrinogen kinetics in sepsis: a prospective observational study.

ABSTRACT:

Background

The measurement of circulating substrate concentrations does not provide information about substrate kinetics. It, therefore, remains unclear if a decrease in plasma concentration of albumin, as seen during critical illness, is a consequence of suppressed production in the liver or increased peripheral clearance. In this study, using stable isotope tracer infusions, we measured albumin and fibrinogen kinetics in septic patients and in a control group of non-septic subjects.

Methods

With the approval from the institutional Research Ethics Board and after obtaining written informed consent from patients or their substitute decision maker, mechanically ventilated patients with sepsis and patients scheduled for elective coronary artery bypass grafting were enrolled. P

SUBMITTER: Omiya K 

PROVIDER: S-EPMC8684235 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature