Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring.

ABSTRACT: Cognitive flexibility, the ability to alter strategy according to changing stimulus-response-reward relationships, is critical for updating learned behavior. Attentional set-shifting, a test of cognitive flexibility, depends on the activity of prefrontal cortex (PFC). It remains unclear, however, what role PFC neurons play to support set-shifting. Using optogenetics and two-photon calcium imaging, we demonstrate that medial PFC activity does not bias sensorimotor responses during set-shifting, but rather enables set-shifting by encoding trial feedback information, a role it has been known to play in other contexts. Unexpectedly, the functional properties of PFC cells did not vary with their efferent projection targets. Instead, representations of trial feedback formed a topological gradien

SUBMITTER: Spellman T 

PROVIDER: S-EPMC8684294 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature