Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia.

ABSTRACT:

Purpose

Proper refractive development of the eye, termed emmetropization, is critical for focused vision and is impacted by both genetic determinants and several visual environment factors. Improper emmetropization caused by genetic variants can lead to congenital hyperopia, which is characterized by small eyes and relatively short ocular axial length. To date, variants in only four genes have been firmly associated with human hyperopia, one of which is MFRP. Zebrafish mfrp mutants also have hyperopia and, similar to reports in mice, exhibit increased macrophage recruitment to the retina. The goal of this research was to examine the effects of macrophage ablation on emmetropization and mfrp-related hyperopia.

Methods

We utilized a chemically inducible, cell-specific ablation

SUBMITTER: Brandt ZJ 

PROVIDER: S-EPMC8684298 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature