An aged immune system drives senescence and ageing of solid organs.

ABSTRACT: Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly^1,2. To define the contribution of immune system ageing to organism ageing, here we selectively deleted Ercc1, which encodes a crucial DNA repair protein^3,4, in mouse haematopoietic cells to increase the burden of endogenous DNA damage and thereby senescence^5-7 in the immune system only. We show that Vav-iCre^+/-;Ercc1^-/fl mice were healthy into adulthood, then displayed premature onset of immunosenescence characterized by attrition and senescence of specific immune cell populations and impaired immune function, similar to changes that occur during ageing in wild-type mice^8-10. Notably, non-lymphoid organs also showed in

SUBMITTER: Yousefzadeh MJ 

PROVIDER: S-EPMC8684299 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature