Genetic Variants in METTL14 are Associated with the Risk of Acute Lymphoblastic Leukemia in Southern Chinese Children: A Five-Center Case-Control Study.

ABSTRACT:

Background/aim

Acute lymphoblastic leukemia (ALL) is the most common form of pediatric cancer. METTL14, an N⁶-methyladenosine (m⁶A) modification protein, plays several roles in cancer development and is involved in the pathogenesis of various types of cancers. However, the role of METTL14 gene single nucleotide polymorphisms (SNPs) in pediatric ALL susceptibility remains to be investigated.

Methods

A case-control design and multinomial logistic regression were used to develop models to estimate the overall risk for pediatric ALL and three METTL14 gene SNPs (rs298982 G/A, rs298981 A/G and rs1064034 T/A) in 808 cases and 1340 controls, which were genotyped using a TaqMan assay. The associations were estimated by odds ratios (ORs) with

SUBMITTER: Luo A 

PROVIDER: S-EPMC8684373 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature