Production of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors.

ABSTRACT:

Context

Testicular adrenal rest tumors (TART) are a common complication in males with classic 21-hydroxylase deficiency (21OHD). TART are likely to contribute to the androgen excess in 21OHD patients, but a direct quantification of steroidogenesis from these tumors has not been yet done.

Objective

We aimed to define the production of 11-oxygenated 19-carbon (11oxC19) steroids by TART.

Methods

Using liquid chromatography-tandem mass spectrometry, steroids were measured in left (n = 7) and right (n = 4) spermatic vein and simultaneously drawn peripheral blood (n = 7) samples from 7 men with 21OHD and TART. For comparison, we also measured the peripheral steroid concentrations in 5 adrenalectomized patients and 12 age- and BMI-matched controls. Additionally, steroids wer

SUBMITTER: Schroder MAM 

PROVIDER: S-EPMC8684463 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature