Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications.

ABSTRACT:

Context

Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications.

Objective

We aimed to assess whether kisspeptin levels are altered in women with antenatal complications.

Methods

Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March

SUBMITTER: Abbara A 

PROVIDER: S-EPMC8684464 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature