Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.

ABSTRACT:

Context

Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear.

Objective

To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function.

Methods

This is a prespecified secondary analysis of the Vitamin D and Type 2 Diabetes study. Overweight/obese adults at high risk for type 2 diabetes (prediabetes) were randomly treated with vitamin D3 4000 IU or matching placebo daily for 24 months.

Main outcome

Disposition index (DI), as an estimate of β-cell function, was calculated as the product of Homeostasis Model Assessment 2 indices derived from C-peptide values (HOMA2%Scpep) and C-peptide response during the first 30 minutes of a 75-g oral glucose tolerance te

SUBMITTER: Rasouli N 

PROVIDER: S-EPMC8684490 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature