Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer's Disease.

ABSTRACT:

Objectives

This study compares glycoproteomes in Thai Alzheimer's disease (AD) patients with those of cognitively normal individuals.

Methods

Study participants included outpatients with clinically diagnosed AD (N = 136) and healthy controls without cognitive impairment (N = 183). Blood samples were collected from all participants for biochemical analysis and for Apolipoprotein E (APOE) genotyping by real-time TaqMan PCR assays. Comparative serum glycoproteomic profiling by liquid chromatography-tandem mass spectrometry was then performed to identify differentially abundant proteins with functional relevance.

Results

Statistical differences in age, educational level, and APOE ɛ3/ɛ4 and ɛ4/ɛ4 haplotype frequencies were found between the AD a

SUBMITTER: Kerdsaeng N 

PROVIDER: S-EPMC8684523 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature