Chemical and Biochemical Reactivity of the Reduced Forms of Nicotinamide Riboside.

ABSTRACT: All life forms require nicotinamide adenine dinucleotide, NAD⁺, and its reduced form NADH. They are redox partners in hundreds of cellular enzymatic reactions. Changes in the intracellular levels of total NAD (NAD⁺ + NADH) and the (NAD⁺/NADH) ratio can cause cellular dysfunction. When not present in protein complexes, NADH and its phosphorylated form NADPH degrade through intricate mechanisms. Replenishment of a declining total NAD pool can be achieved with biosynthetic precursors that include one of the reduced forms of nicotinamide riboside (NR⁺), NRH. NRH, like NADH and NADPH, is prone to degradation via oxidation, hydration, and isomerization and, as such, is an excellent model compound to rationalize the nonenzymatic metabolism of NAD(P)H in

SUBMITTER: Makarov MV 

PROVIDER: S-EPMC8684594 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature