Guideline-discordant dosing of direct-acting oral anticoagulants in the veterans health administration.

ABSTRACT:

Background

Clear guidelines exist to guide the dosing of direct-acting oral anticoagulants (DOACs). It is not known how consistently these guidelines are followed in practice.

Methods

We studied patients from the Veterans Health Administration (VA) with non-valvular atrial fibrillation who received DOACs (dabigatran, rivaroxaban, apixaban) between 2010 and 2016. We used patient characteristics (age, creatinine, body mass) to identify which patients met guideline recommendations for low-dose therapy and which for full-dose therapy. We examined how often patient dosing was concordant with these recommendations. We examined variation in guideline-concordant dosing by site of care and over time. We examined patient-level predictors of guideline-concordant dosing using multivaria

SUBMITTER: Rose AJ 

PROVIDER: S-EPMC8684634 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature