Transcriptome-wide association study identified candidate genes associated with gut microbiota.

ABSTRACT:

Background

Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities. The specific mechanism of host-regulated gene expression affecting gut microbiota has not been elucidated yet. Here we conducted a transcriptome-wide association study (TWAS) for gut microbiota by leveraging expression imputation from large-scale GWAS data sets.

Results

TWAS detected multiple tissue-specific candidate genes for gut microbiota, such as FUT2 for genus Bifidobacterium in transverse colon (P_PERM.ANL = 1.68 × 10^-3) and SFTPD for an unclassified genus of Proteobacteria in transverse colon (P_PERM.ANL = 5.69 × 10^-3). Fine mapping replicated 3 candidate ge

SUBMITTER: Pan C 

PROVIDER: S-EPMC8684646 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature