Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review.

ABSTRACT: Mild traumatic brain injuries (mTBIs) are a prevalent form of injury that can result in persistent neurological impairments. Microglial activation has become increasingly recognized as a key process regulating the pathology of white matter in a wide range of brain injury and disease contexts. As white matter damage is known to be a major contributor to the impairments that follow mTBI, microglia have rightfully become a common target of investigation for the development of mTBI therapies and biomarkers. Recent work has demonstrated that the efficacy of microglial manipulation as a therapeutic intervention following injury or disease is highly time-sensitive, emphasizing the importance of advancing our understanding of the dynamics of post-mTBI microglial activation from onset to resolution

SUBMITTER: Velayudhan PS 

PROVIDER: S-EPMC8684664 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature