Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma.

ABSTRACT:

Background

Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases. However, the role of circRNA in the etiopathogenesis of middle ear cholesteatoma is rarely investigated so far. We aimed to investigate the differential expression profiling of circRNAs between acquired middle ear cholesteatoma and normal skin, and to identify potential circRNAs contributing to the etiopathogenesis of middle ear cholesteatoma. Microarray analysis and functional prediction were performed to investigate the circRNA expression profiling between middle ear cholesteatoma and normal skin. Validation of differentially expressed circRNAs was conducted by qRT-PCR. Prediction of m

SUBMITTER: Xie S 

PROVIDER: S-EPMC8684697 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature