The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis.

ABSTRACT: Control of centrosome assembly is critical for cell division, intracellular trafficking, and cilia. Regulation of centrosome number occurs through the precise duplication of centrioles that reside in centrosomes. Here we explored transcriptional control of centriole assembly and find that the RNA splicing factor SON is specifically required for completing procentriole assembly. Whole genome mRNA sequencing identified genes whose splicing and expression are affected by the reduction of SON, with an enrichment in genes involved in the microtubule (MT) cytoskeleton, centrosome, and centriolar satellites. SON is required for the proper splicing and expression of CEP131, which encodes a major centriolar satellite protein and is required to organize the trafficking and MT network around t

SUBMITTER: Stemm-Wolf AJ 

PROVIDER: S-EPMC8684746 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature