Ontology highlight
ABSTRACT:
SUBMITTER: Denarier E
PROVIDER: S-EPMC8684761 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Denarier E E Ecklund K H KH Berthier G G Favier A A O'Toole E T ET Gory-Fauré S S De Macedo L L Delphin C C Andrieux A A Markus S M SM Boscheron C C
Molecular biology of the cell 20210811 20
Mutations in the genes that encode α- and β-tubulin underlie many neurological diseases, most notably malformations in cortical development. In addition to revealing the molecular basis for disease etiology, studying such mutations can provide insight into microtubule function and the role of the large family of microtubule effectors. In this study, we use budding yeast to model one such mutation-Gly436Arg in α-tubulin, which is causative of malformations in cortical development-in order to unde ...[more]