Folate fortification of food: Insufficient for women with epilepsy.

ABSTRACT:

Objective

Folic acid supplementation during the periconceptual period has been shown to improve cognitive outcomes in children of women with epilepsy taking anti-seizure medications (ASMs). The dose of folic acid necessary to provide positive cognitive outcomes is unclear. In many countries including the United States, food is fortified with folic acid, but no data exist on how food fortification may affect cognition in children with fetal-ASM exposure. This study evaluated the effect of dietary folate from natural folates plus folic acid fortification, separate from folic acid vitamin supplements, on age-6 year IQ in children with fetal-ASM exposure.

Methods

Data from the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study were retrospectively analyzed for this i

SUBMITTER: Sadat-Hossieny Z 

PROVIDER: S-EPMC8684790 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature